2-Chloro-N-{5-[(4R,5R,10S)-dehydroabiet-4-yl]-1,3,4-thiadiazol-2-yl}benzamide
نویسندگان
چکیده
There are two independent mol-ecules in the asymmetric unit of the title compound, C(28)H(32)ClN(3)OS (systematic name: 2-chloro-N-{5-[(1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octa-hydro-phenanthren-1-yl]-1,3,4-thia-diazol-2-yl}benzamide). In each mol-ecule, the cyclo-hexyl ring attached to the thia-diazole fragment adopts a classic chair conformation with two of its two methyl groups in the axial positions. In the crystal, pairs of inter-molecular N-H⋯N hydrogen bonds link the mol-ecules into centrosymmetric dimers, which are further linked via C-H⋯π inter-actions.
منابع مشابه
N-(5-Benzylsulfanyl-1,3,4-thiadiazol-2-yl)-2-(piperidin-1-yl)acetamide
The title compound, C16H20N4OS2, was synthesized by the reaction of 2-benzyl-sulfanyl-5-chloro-acetamido-1,3,4-thia-diazole and piperidine in a 1:2 ratio. The planes of the acetamide and 1,3,4-thia-diazole units are twisted by 10.8 (4)°. The thia-diazole S atom and the acetamide O atom are syn-oriented due to a hypervalent S⋯O inter-action of 2.628 (4) Å. In the crystal, mol-ecules form centros...
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In the title compound, C(14)H(16)ClN(3)O(2)S, the dihedral angle between the 4-chloro-phenyl and 1,3,4-oxadiazole rings is 67.1 (1)° and the orientation of the amide N-H and C=O bonds is anti. In the crystal, mol-ecules are linked by N-H⋯O and N-H⋯S hydrogen bonds.
متن کامل(E)-N-(4-Chlorobenzylidene)-5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine
The title compound, C(16)H(12)ClN(3)S, was synthesized by the reaction of 5-(4-methyl-phen-yl)-1,3,4-thia-diazol-2-amine and 4-chloro-benzaldehyde. The thia-diazole ring is essentially planar with mean deviation of 0.0042 Å.
متن کاملN-(5-Ethoxy-1,3,4-thiadiazol-2-yl)benzamide
In the title compound, C(11)H(11)N(3)O(2)S, the dihedral angle between the thia-diazole and phenyl rings is 28.08 (7)°. In the crystal, mol-ecules are linked into an inversion dimer by a pair of inter-molecular N-H⋯N hydrogen bonds with an R(2) (2)(8) graph-set motif.
متن کاملN-(4-Methylphenyl)benzamide
The structure of the title compound, C(14)H(13)NO, resembles those of N-(2-chloro-phen-yl)benzamide, 2-chloro-N-phenyl-benzamide, N-(2,3-dichloro-phen-yl)benzamide, N-(3,4-dichloro-phen-yl)benzamide and 2-chloro-N-(2-chloro-phen-yl)benzamide with similar bond parameters. The benzene and methylphenyl rings have a dihedral angle of 63.41 (5)°, while the amide group makes a dihedral angle of 20.5 ...
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عنوان ژورنال:
دوره 67 شماره
صفحات -
تاریخ انتشار 2011